The p53 gene is an important tumour suppressor and is involved in apoptosis and cell cycle arrest, whereas mutations of p53 is associated with human cancers and the onset of MDR in a broad range of malignancies (Schmitt and Lowe, 1999; Norbury and Zhivotovsky, 2004; Pommier et al, 2004; Kim, 2005). This evidence concerns the gene TP53 and neoplasm.