In addition, evaluating WTH3's expression levels in 11 cancer cell lines with defined p53 status supported this positive influence as the cell lines with wild-type p53 produced much higher levels of WTH3 transcript than those containing mutated or attenuated p53. We also noticed that the observed correlation between these two genes in breast cancer cell lines was not related to their oestrogen receptor positive or negative condition. This evidence concerns the gene TP53 and cancer.