The subset of BSI high/Bcl-2− cases was associated with the best prognosis (5-year DFS 82.6%; 5-year OS 87.1%); among patients with the BSI high/Bcl-2+ phenotype, outcome was associated with an intermediate prognosis (5-year DFS 68.8%; 5-year OS 73.1%) (Table 3), whereas patients harbouring the BSI low/Bcl-2− or + phenotype were found to have the worst prognosis (5-year DFS 56.8 or 41.4%; 5-year OS 61.4 or 59.5%) (Figure 4). Here, BCL2 is linked to bathing suit ichthyosis.