MCL1 and BCL2 are commonly amplified and overexpressed in human MM (Carrasco et al., 2006; Le Gouill et al., 2004; Spets et al., 2002); however, they were downregulated in the Eμ-xbp-1s tumors (Figure 6B), but not in premalignant B cells. Here, BCL2 is linked to Miyoshi myopathy.