Tot [26] and Jacquemier and colleagues [9] found lower rates of KRT5/6 positivity (25% and 44.7%, respectively) than in the present study, but Tot used a different antibody from that used in the present study and, in contrast with the present study, Jacquemier and colleagues included medullary carcinomas that were ER positive and PR positive in 10.5% and 51.3% of cases, respectively. This evidence concerns the gene ESR1 and medullary thyroid gland carcinoma.