Intravitreal injection of recombinant TGFβ into the rat eye [32] has been shown to produce ASC following 15 weeks post injection, however the ASC were not well defined and were accompanied by a number of other lens defects, including cortical clouding, disrupted bow region, nucleated fiber cells, vacuolation of fiber cells, and posterior subcapsular cataracts containing swollen and degenerating cells. Here, TGFB1 is linked to Posterior polar cataract.