Of interest, the prognostic value of these three NFκB and AP-1 regulated genes measured by separation between RFS curves, appeared greater for the younger age cases (≤ age 45 years) in which metastatic relapses occurred earlier and more frequently relative to the older age cases (≥ 70 years), despite the fact that tumors from both age cohorts were indistinguishable with regard to standard prognostic tumor markers, use of systemic adjuvant therapy, and level of expression for each of these genes. This evidence concerns the gene FOSB and neoplasm.