Given the fact that our TAM-resistant breast cancer models, MCF7/HER2 and BT474, showed activation of both NFκB and AP-1 transcription factor complexes by both DNA-binding and reporter gene assays, we performed an exploratory analysis in a UCSF dataset of 54 ER-positive, node-negative primary human breast cancers looking for prognostic genes known to be upregulated by activated NFκB and AP-1. The gene discussed is FOS; the disease is breast cancer.