In line with this data, it has further been shown that JunB expression is silenced in CML by hypermethylation[50] and it functions as a negative regulator of B-lymphoid proliferation[51] However, on the contrary to the expectation, p73 null mice failed to develop spontaneous lymphoma formation even after two years[52]. Here, JUNB is linked to chronic myelogenous leukemia, BCR-ABL1 positive.