The natural metabolites hypothemycin (0.5 μg/Ml) and O-methyl deoxybouvardin (RA-VII) (100 nM) have also been shown to induce the ubiquitin-dependent degradation of cyclin D1 in transformed NIH3T3 mouse and human colon cancer cell lines respectively [95,96]. This evidence concerns the gene CCND1 and colonic neoplasm.