This hypoglycaemia was due to increased insulin secretion, as the insulin/glucose ratio values in β-Hnf4a-KO versus control mice were 29.8 ± 12.0 versus 5.6 ± 1.5 (p = 0.01), while insulin values were 23.9 ± 6.9 pmol/l versus 11.1 ± 3.3 pmol/l (p = 0.053), respectively (Figure 3B). Here, PPIB is linked to Hypoglycemia.