EDNRA and neoplasm: All these molecules are known to be involved in cancer process, some being identified as tumour suppressor genes (e.g. GPR54 and CLDN23) (Kotani et al, 2001; Katoh and Katoh, 2003) and others related to angiogenesis (e.g. CXL1 and EDNRA) (Hosoda et al, 1992; Shintani et al, 2004) or cell migration capacities (e.g. PLAU) (Guo et al, 2002).