Known tumour suppressor genes, although not included in this list, were noted as downregulated in the array analysis for example, the FHIT (LBFC=−5.39) at 3p14.2; ST7 (LBFC=−2.95) at 7q31 or CLDN23 (LBFC=−4.58) at 8p23.1. The gene discussed is CLDN23; the disease is neoplasm.