We have previously observed that the Mcm2LI provides information with respect to disease-free survival in PCa patients undergoing radical prostatectomy (Meng et al, 2001), and our findings are also in keeping with the recent report that Mcm7 amplification and overexpression is associated with worse tumour grade and relapse (Ren et al, 2006). Here, MCM7 is linked to posterior cortical atrophy.