PTHLH and breast carcinoma: Subsequent investigations conducted by Shen and Falzon utilised cell lines derived from three different tissues (prostate, colonic and breast; PC3, LoVo and MCF-7, respectively), which showed that overexpression of PTHrP causes a significant increase in prostate and colon cancer cell adhesion to collagen type I, fibronectin and laminin and an increase in breast cancer cell adhesion to laminin only (Shen and Falzon, 2003a, 2003b, 2005; Shen et al, 2004).