Recent studies, however, have called into question the role of FGFR1 as the 'amplicon driver', given that not all cell lines and breast cancers with 8p11.2-p12 amplification overexpressed the FGFR1 gene and that FGFR1 protein and mRNA expression was much more pervasive than gene amplification [7-9]. The gene discussed is FGFR1; the disease is breast carcinoma.