On multivariate Cox hazard analysis adjusted for tumour grade, size and lymph node status, for ER status, and for FGFR1 amplification, it was found that the FGFR1 amplification was a significant predictor of poor overall survival independent of the other known prognostic parameters (P < 0.04) (Table 3). This evidence concerns the gene FGFR1 and neoplasm.