FGFR1 and breast carcinoma: Although large studies correlating FGFR1 amplification with mRNA and protein expression are still needed, the functional data demonstrating that FGFR1 signalling is required for the survival of breast cancer cells harbouring FGFR1 amplification [14], the relatively high prevalence of FGFR1 amplification in breast cancer and the independent prognostic information provided by FGFR1 amplification status support the idea that this gene may be a useful therapeutic target for a subgroup of breast cancer patients with FGFR1 gene amplification [14].