EPO and neoplasm: The results of this study have shown that ‘poorly differentiated’ HCC has a higher degree of vascularization than ‘moderately’ and ‘well-differentiated’ HCC, respectively, and that Epo expression in tumour cells and EpoR expression in both tumour and endothelial cells increases in parallel with the grade of malignancy and is highly correlated with the extent of angiogenesis.