From our observations, it appears that PPARγ is correlated with aninhibition of cell proliferation that is not accompanied by any increase ofapoptosis: in specimens of colon cancer from patients undergoing surgery,the expression of PPARγ was higher than in mucosa specimens.Together with this increase, reduced c-Myc and PCNA protein contents wereobserved, indicating lower cell proliferation in tumor than in mucosaspecimens. This evidence concerns the gene PCNA and neoplasm.