Having genotyped individualsfrom three separate cohorts (1997 subjects with T2DM, 2444nondiabetic children, and 1061 middle-aged controls—all from asimilar area in Tayside, Scotland) for the PPARG Pro12Alaand C1431T polymorphisms, they concluded that the Ala12 variantwas underrepresented in the T2DM population when compared withsimilarly aged nondiabetic adults (OR = 0.74, P = .0006). The gene discussed is PPARG; the disease is type 2 diabetes mellitus.