When PCOS subjects with the Pro allele and theAla allele of PPAR-γ were compared, they foundthat having the Ala allele of this nuclear receptor gene wasrelated with reduced androgen levels, a lower Ferriman-Gallweyscore, a lower insulin resistance index, a lower body mass index,and a lower waist-to-hip ratio [181]. The gene discussed is PPARG; the disease is polycystic ovary syndrome.