IARS1 and polycystic ovary syndrome: Although initially noevidence for linkage or association with PCOS was found withIRS-1 in a family-based study conducted by Urbaneket al. [35], the potential roles of these SNPs of IRS genes ininsulin resistance have further been investigated in PCOS.Sir-Petermann et al. reported a higher frequency of the Arg972IRS-1 allele in PCOS patients in Chilean population[142].