Consequently, Conway et al. [132] analyzed the sequence of the tyrosine kinase domain of INSR in 22 hyperinsulinemic patients with PCOS and Talbot et al. [133] investigated the mutations by molecular scanning of the entire coding region of INS in 24 hyperinsulinemic women with PCOS, and none of these groupsdetected any significant mutations related to insulin resistancein PCOS [133]. The gene discussed is INS; the disease is polycystic ovary syndrome.