Legro et al. reported that affected sisters of women with PCOS (whofulfill criteria for the diagnosis of PCOS, and those withhyperandrogenemia) had high insulin levels and low fasting glucoseto insulin ratios [18], and the brothers of women with PCOS had increased dehydroepiandrosterone (DHEAS) levels [19]. Here, INS is linked to polycystic ovary syndrome.