Likewise,the lack of a clear-cut association to the polymorphisms does notrule out the implications of PPARg on the pathogenesis of PCOS.Even though genetic association studies do not clearly establishany link between PCOS and PPAR-γ polymorphisms,functional investigations still point out the suspicious role ofPPAR-γ on PCOS. This evidence concerns the gene PPARG and polycystic ovary syndrome.