PLOD1 and polycystic ovary syndrome: The hypothesis that an activating mutation in the LHreceptor gene might be a cause of hyperandrogenism in patientswith PCOS having normal serum LH concentrations and raisedandrogen levels was tested using linkage analysis in families withmultiple cases of PCOS, and five families in whom polymorphicmarkers close to the LH receptor gene segregate with thesyndrome were identified [104].