IRS1 and polycystic ovary syndrome: Besides, they showed gene-dosage effects onfasting insulin levels for Gly972Arg IRS-1 and on 2-hplasma glucose levels during oral glucose tolerance test (OGTT)for Gly1057Asp IRS-2 in women with PCOS, while no novelmutations have been found in these genes by direct sequencing[143].