Secondly, how to assign affected status of men in PCOSfamilies remains obscure although several clinical and biochemicalcharacteristics have been suggested for the male phenotypeincluding premature baldness, increased pilosity, increased DHEASlevels, exaggerated responses to GnRH or ACTH, and insulinresistance and glucose intolerance [109]. This evidence concerns the gene GNRH1 and Glucose intolerance.