In a study assessing the association ofPCOS with 15 genomic variants previously described to influenceinsulin resistance, obesity, and/or type-2 diabetes mellitus,San Millán et al. failed to find any associationbetween PCOS and these two common polymorphisms of the adiponectin gene [163]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.