IRS1 and polycystic ovary syndrome: Although the IRS-1 genotype was not found to be associated with anyclinical or hormonal measures in nondiabetic PCOS subjects,carrying IRS-2 Gly/Gly genotype was associated withsignificantly higher glucose levels in 2-h OGTT compared withcarrying Gly/Asp and Asp/Asp genotypes [144].