Contrary to this report, El Mkadem et al. could notfind any differences in the distribution of IRS-1Gly972Arg and IRS-2 Gly1057Asp alleles in PCOS patientsand controls; however, they demonstrated that the Gly972ArgIRS-1 was more prevalent in insulin-resistant patientscompared with the noninsulin resistant patients or controlsubjects [143]. This evidence concerns the gene IRS2 and polycystic ovary syndrome.