In addition, a recent, yet-to-be-publishedsymposium talk reported that macrophage-specificPparg-null mice are glucose intolerant and exhibitincreased sensitivity to HFD-induced insulin resistance [58].Thus, PPARγ orchestrates multiple beneficial activities inmacrophages that could be harnessed for the development ofadvanced therapies for atherosclerosis. The gene discussed is PPARG; the disease is Insulin resistance.