LEP and obesity due to melanocortin 4 receptor deficiency: However, the mice were protected from the adipocytehypertrophy, dyslipidemia, obesity, and steatosis that occur inresponse to either HFD or impaired leptin signaling [87].Quelling of obesity in these mice was associated with upregulationof genes that control lipid catabolism and adaptive thermogenesisin both BAT and WAT; reassuringly, the same genes are induced inresponse to systemic administration of a PPARδ ligand[87].