Moreover, high-fat-diet-induced adiposity was stronglyinhibited by activation of PPARβ/δ in adipose tissue.Whether PPARβ/δ is able to control inflammatory geneexpression in WAT during diet-induced obesity is still unclear.Inasmuch as inflammatory gene expression is linked to adiposity,it could be hypothesized that inflammatory gene expression will besuppressed by PPARβ/δ activation. This evidence concerns the gene PPARD and obesity due to melanocortin 4 receptor deficiency.