For example,PPARα-null or PPARγ-adiposeKO mice areprotected form insulin resistance and obesity caused by HFD.Studies in genetically long- or short-lived mice together with thestudies involving CR suggest that PPARs play an important role ininsulin action, lipid metabolism, immunity, and inflammation aswell as regulation of aging and longevity. The gene discussed is PPARA; the disease is obesity disorder.