In contrast, the VP2 and VP2121‐130 transgenic mice showed decreases in the percent of CD8+ cells infiltrating the brain (20 ± 2.1% and 15 ± 0.7% respectively) and increases in the percent of CD4+ cells (43 ± 5.7% and 43 ± 5.1% respectively) after 7 days of infection with TMEV (Figure 4B,C). The gene discussed is CD4; the disease is infection.