The limitations of the study are the small sample size (and thus limited generalizabililty), the absence of any EBV-specific CD8+ T cell functional measurements (which may be important in protective immunity), and the absence of any measurements of T or B cell activation (which are reported to have a role in the immunopathogenesis of AIDS-related non-Hodgkin's lymphoma). The gene discussed is CD8A; the disease is AIDS.