ESR1 and neoplasm: Yet, TP53 status remained significantly linked to a response in univariate analyses, irrespective of the stratification (age, T stage or tumor grade, KRT5/6 or 17 presence, CDKN2A cytoplasmic staining [p16], ERBB2 mRNA, or ESR1 protein expression) in Mantel-Haenszel tests (Figure 1A).