In contrast, in RCC cells, PHD3 expression was dominantly dependent on HIF-2α (Figure 1, panels E and F) whether the cells expressed electrophoretically normal HIF-1α (RCC4), HIF-1α protein with enhanced electrophoretic mobility (A498) or no immunoreactive HIF-1α protein (786-0). The gene discussed is EGLN3; the disease is renal cell carcinoma.