Interestingly, clinical RCC shows an unusual bias to greater HIF-2α rather than HIF-1α expression (Krieg et al, 2000; Turner et al, 2002), and in kidneys from patients with VHL disease, greater HIF-2α expression is associated with more advanced lesions (Mandriota et al, 2002). The gene discussed is EPAS1; the disease is renal cell carcinoma.