As with the in vitro model (Eley and Tisdale, 2007), inhibition of the phosphorylation of PKR also attenuated the increased protein degradation in the skeletal muscle of cachectic mice through repression of the induction of proteasome expression and activity concomitant with a significantly reduced nuclear accumulation of NF-κB down to values found in non-tumour-bearing animals. Here, EIF2AK2 is linked to neoplasm.