EIF2AK2 and neoplasm: The results depicted in Figure 5 show a significant upregulation of NF-κB in gastrocnemius muscle of mice bearing the MAC16 tumour, in comparison with non-tumour-bearing control, and a reduction in NF-κB DNA-binding activity in gastrocnemius muscle of mice treated with the PKR inhibitor at both dose levels, down to values found in non-tumour-bearing controls.