The ability of these RAMBAs to induce differentiation in breast cancer cells may be of significance in light of recent findings which suggest that downregulated expressions of CK 18 (Korsching et al, 2002; Woelfle et al, 2004; Schaller and Buhler, 2005) and/or E-cadherin/ER-α (Nass et al, 2000; Kowalsski et al, 2003) promote progression of human breast cancer. The gene discussed is CDH1; the disease is breast carcinoma.