CCND1 and cancer: Given the well-established involvement of cyclins in the regulation of cell cycle progression and the previous findings that cyclin D1 is overexpressed in many cancers and cancer cell lines (Teixeira and Pratt, 1997; Zhou et al, 1997; Niu et al, 2001), we investigated the effects of our RAMBAs on the level of cyclin D1 expression.