There have been several reports of clinical factors associated with EGFR mutations, and per the univariate analysis, mutation frequency is high in patients of East Asian ethnicity, females, never-smokers and adenocarcinomas (Kosaka et al, 2004; Paez et al, 2004; Shigematsu et al, 2005; Tokumo et al, 2005). Here, EGFR is linked to adenocarcinoma.