For example, EGF, transforming growth factor α, insulin-like growth factor 1, interleukin 6, keratinocyte growth factor, and other fibroblast growth factor family members are expressed in advanced prostate cancers and are believed to be important in fueling androgen-independent growth (Culig et al. 1994; Yeh et al. 1999). The gene discussed is EGF; the disease is Familial prostate cancer.