ANGPT4 and neoplasm: There were higher levels of Ang-1, Ang-2 and Ang-3 expression seen in patients with poor prognosis, i.e., NPI-3 tumours (NPI >5.4), although this did not reach significance (for Ang-1 NPI-1: 3.69 ± 2.5; NPI-2: 1.8 ± 1.4; NPI-3: 806 ± 805; P = 0.34) (for Ang-3: NPI-1 0.38 ± 0.28; NPI-2: 85.7 ± 84.3; NPI-3: 1000 ± 961; P = 0.32).