The results showed that Ang-1 and Ang-3 expression were increased with higher grade of tumour, i.e. Grade-3 (173 ± 170 & 212 ± 108, respectively) compared with Grade-1 (3.2 ± 2.9 & 1.5 ± 1.3, for Ang-1 and Ang-3 respectively) (Figure 3). This evidence concerns the gene ANGPT4 and neoplasm.