ANGPT4 and metastatic neoplasm: Those patients with metastatic disease had low, but insignificant levels of Ang-1, Ang-2, Ang-3 and Tie-2 expression compared to patients who remained disease free (metastatic group: Ang-1: 0.22 ± 0.16, Ang-2: 0.73 ± 1.8, Ang-3: 0.44 ± 0.42, Tie-2: 3.3 ± 2.5 vs disease free: Ang-1: 2.75 ± 1.9, Ang-2: 2314 ± 1525, Ang-3: 50.7 ± 44.5, Tie-2: 8.5 ± 6.5 respectively) (Figure 4A).