Oestrogen receptor positive breast tissues (ER ve+) had low level of Ang-2 and Ang-3 compared to ER negative tumours (ER ve-) (ERve+ for Ang-2: 120 ± 75, Ang-3: 2.4 ± 1.6 vs ERve- for Ang-2: 2970 ± 1973 & for Ang-3: 65 ± 85). The gene discussed is ANGPT4; the disease is neoplasm.