BRCA1 and ovarian cancer: BRCAPRO estimates the probability that a consultand carries a deleterious mutation in the BRCA1 [MIM 113705] and BRCA2 [MIM 600185] genes, based on family history of breast and ovarian cancer, while MMRPRO computes the probability of carrying a mutation in the DNA mismatch repair genes MLH1 [MIM 120436], MSH2 [MIM 609309], and MSH6 [MIM 600678] given family history of colorectal and endometrial cancer.