Although the association of fascin expression with lymph node involvement has already been documented for other gastrointestinal cancers such as oesophageal and gastric carcinomas (Hashimoto et al, 2004, 2005a) and also for pulmonary neoplasms (Pelosi et al, 2003a; Choi et al, 2006), we have shown that fascin immunoreactivity in colonic adenocarcinomas is also related to the patterns of lymph node involvement (intra- vs extra-lymph nodal colonisation). This evidence concerns the gene FSCN1 and gastric carcinoma.