Pelosi et al (2003b) also noted a differential distribution of fascin immunoreactivity in mucinous and nonmucinous bronchioloalveolar carcinomas of the lung and fascin transfection in colonic carcinoma cell lines increased the levels of neutral mucin (Jawhari et al, 2003). Although the clinical implications of colorectal mucinous carcinoma are still controversial, a consensus conference on colorectal carcinomas stated that mucinous and signet ring carcinomas, when evaluated jointly, have a poorer prognosis than intestinal-type adenocarcinomas (Compton et al, 2000). Here, MUC5AC is linked to signet ring cell carcinoma.