Cyclin D1 levels are typically under stringent regulation, but aberrant cyclin D1 expression has been implicated as having oncogenic properties in many neoplasias including breast (Arnold and Papanikolaou, 2005), pituitary (Faglia and Spada, 2001), and squamous cell carcinoma (Nadal and Cardesa, 2003). The gene discussed is CCND1; the disease is squamous cell carcinoma.