All three metastatic tumours stained nuclear positive for the AR, thus validating the tumour cells as prostatic in origin (Figure 2, middle panel and data not shown) Although the available sample size is small, all tumours exhibited exclusively modest (1+) nuclear cyclin D1 staining (Figure 2, right panel and data not shown), whereas the surrounding stromal tissue was null for cyclin D1. The gene discussed is CCND1; the disease is neoplasm.