CCND1 and colorectal cancer: Interestingly, a number of colorectal cancer studies have observed cytoplasmic cyclin D1 in tumour specimens (Palmqvist et al, 1998; Handa et al, 1999; McKay et al, 2000; Holland et al, 2001; Khor et al, 2006; Kuramochi et al, 2006) and at least one of these studies has reported that increased cytoplasmic cyclin D1 correlated with low proliferation (Palmqvist et al, 1998).