Interestingly, a number of colorectal cancer studies have observed cytoplasmic cyclin D1 in tumour specimens (Palmqvist et al, 1998; Handa et al, 1999; McKay et al, 2000; Holland et al, 2001; Khor et al, 2006; Kuramochi et al, 2006) and at least one of these studies has reported that increased cytoplasmic cyclin D1 correlated with low proliferation (Palmqvist et al, 1998). This evidence concerns the gene CCND1 and neoplasm.