CCND1 and neoplasm: A series of smaller studies have also reported cyclin D1 induction in tumours compared to normal specimens (Han et al, 1998; Kolar et al, 2000; Murphy et al, 2005) and at least one of these considered all cyclin D1 localisations (including cytoplasmic and perinuclear) as positive, although correlates according to localisation were not considered (Han et al, 1998).