On multivariate analysis of these significant covariates, age (HR 4.19, 95%CI 1.26–13.91, P=0.019), albumin (HR 3.33, 95%CI 1.60–6.90, P=0.001), tumour size (HR 2.48, 95%CI 1.36–4.55, P=0.003) and systemic treatment (HR 2.10, 95%CI 1.45–3.05, P<0.0001) were significant independent predictors of overall survival. This evidence concerns the gene ALB and neoplasm.