ACHE and early-onset autosomal dominant Alzheimer disease: Accordingly, recent studies have explored the roles of the two AChE variants in the response to neuronal injury and neurodegeneration (Perrier et al. 2005; Sternfeld et al. 2000), physical trauma (Shohami et al. 2000), and Alzheimer disease (Darreh-Shori et al. 2004).