Liposarcomas account for about 20% of STS and within this subtype, the myxoid/round-cell liposarcomas characterized by the TLS-CHOP or EWS-CHOP fusions [37] formed a distinct cluster closely related to a subset of SS and MPNST within subcluster S with upregulation of several developmental and ribosomal protein genes (Figure 1). Here, EWSR1 is linked to telomere syndrome.