Interestingly, also the MFH/UPS, the leiomyosarcomas and the fibrosarcoma that clustered tightly with the dedifferentiated/pleomorphic liposarcomas showed amplification of CDK4 and MDM2 when analyzed by array comparative genomic hybridization (data not shown) or Southern blot analysis [23]. The gene discussed is CDK4; the disease is leiomyosarcoma.