Developmental genes including members of the Wnt receptor signaling pathway, e.g. DAAM1, FZD8, MYC, PRICKLE1, SFRP1 and WISP2, and neurogenesis genes, e.g. CPNE6, EFNA5, FEZ2, LHX2, MDK and NTNG1 were upregulated in the myxoid/round-cell liposarcomas as compared to the dedifferentiated/pleomorphic liposarcomas, as were several ribosomal protein genes and genes involved in adhesion and amino acid metabolism. The gene discussed is MDK; the disease is round cell liposarcoma.