After excluding local recurrences, metastases, samples treated with preoperative chemotherapy, the single SS and 3 MPNST (that were outliers from cluster S), the 11 leiomyosarcomas with a distinct profile, and the dedifferentiated/pleomorphic liposarcomas with the MDM2-CDK4 double amplification, 89 primary STS remained for the analysis. This evidence concerns the gene CDK4 and malignant peripheral nerve sheath tumor.