Interestingly, mutations in the lamin A-type gene (LMNA) that cause human diseases called "laminopathies" can also abrogate the nuclear peripheral location of the 4q subtelomere [14], and so 4q35.2 gene expression might be dictated by the interaction of chromatin and/or DNA with components lining the inner nuclear membrane, such as the lamins known to recruit transcriptional regulators [32]. Here, LMNA is linked to laminopathy.