It has been reported that proinflammatory genotypes of the interleukin-1 loci were associated with a significantly increased risk of a chronic hypochlorhydric response to H. pylori infection and gastric cancer in a Caucasian population, presumably by altering IL-1β levels in the stomach [12,13], but an influence of IL-1β gene polymorphisms on susceptibility of cachexia from gastric cancer has not been evaluated. The gene discussed is IL1B; the disease is gastric cancer.