In addition, previous studies by Munarini et al (2002) have shown that overexpression of EphB4 in the breast of mice in the context of neuT results in highly malignant breast cancers that metastasise to the lung, a phenomenon that was uniformly absent in tumours of mice that overexpressed neuT only (Munarini et al, 2002). Here, EPHB4 is linked to breast cancer.