VEGFC and breast cancer: Using animal models, VEGF-C induced formation of new lymph vessels in the chick chorioallantoic membrane (Oh et al, 1997), induced lymphangiogenesis around islet of Langerhans in the pancreas which, normally, are not surrounded with lymphatics (Mandriota et al, 2001), induced hyperplasia and dilatation of the dermal lymphatics when overexpressed in transgenic mice (Jeltsch et al, 1997) and increased LVD and LN metastasis in xenografted breast cancer (Skobe et al, 2001).