Overexpression of VEGF-C and -D in experimental tumour models has been found to be significantly associated with the formation of new lymphatics (Skobe et al, 2001; Stacker et al, 2001; Von Marschall et al, 2005), however, their effect in human cancers is a matter of controversy with some studies finding a significant association with tumour angiogenesis, lymphangiogenesis, lymph node (LN) status and prognosis (Nakamura et al, 2003a, 2005) and others no relationships (Currie et al, 2004). This evidence concerns the gene VEGFC and neoplasm.