These include RPS6KB1, APPBP2, and PPM1D (Couch et al, 1999; Barlund et al, 2000a, 2000b; Wu et al, 2001; Bulavin et al, 2002; Li et al, 2002) that also showed strong association between amplification and increased expression in our primary tumour material. The gene discussed is PPM1D; the disease is neoplasm.