WT1 and Nephroblastoma: WT1 mutations have been identified in patients with Wilm’s tumor, WAGR syndrome (Wilm’s tumor, aniridia, genitourinary abnormalities, and retardation-hypospadias and bilateral cryptorchidism may be seen), Denys-Drash syndrome (urogenital abnormalities, renal failure, pseudohermaphroditism, and Wilm’s tumor), Frasier syndrome (male pseudohermaphroditism and progressive glomerulopathy), and isolated diffuse mesangial sclerosis.