Mean levels of HMGB1 were as follows: undetectable in healthy controls, 4.54 ng/ml in infected patients, 2.15 ng/ml in patients with malignant disease, 6.47 ng/ml in trauma patients, and 14.05 ng/ml in patients with disseminated intravascular coagulation [24]. Here, HMGB1 is linked to Disseminated intravascular coagulation.