It has been suggested that HMGB1 has a role as a pro-inflammatory cytokine [21], and HMGB1 has been shown to have many organ-specific biological functions, including inducing fever, anorexia, weight loss, and cytokine production in the brain; inducing acute lung injury and production of pro-inflammatory cytokines/mediators in the lungs; promoting translocation in the gut; inducing arthritis and joint inflammation; affecting heart rhythm; and having bactericidal effects [22]. The gene discussed is HMGB1; the disease is Arthritis.