Inhibition of procaspase-8 cleavage via enhanced binding of c-Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein-long (c-FLIPL) to Fas-associated death domain protein (FADD) also essentially contributes to adhesion-mediated survival in endothelial cells [23] or mediates drug resistance in myeloma cell lines [24]. This evidence concerns the gene FADD and plasma cell myeloma.