Chemotherapeutic treatment success in brain tumours is mainly limited by the blood–brain barrier and the expression of chemoresistance-related proteins like P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), and major vault protein (MVP) also known as lung resistance protein (LRP) (Berger et al, 2001; Bredel, 2001; Spiegl-Kreinecker et al, 2002). Here, MVP is linked to brain neoplasm.