HMGA1 and cancer: HMGA1 proteins are overexpressed in a range of human cancers, notably including pancreatic adenocarcinoma (Abe et al, 2000; Balcerczak et al, 2003; Chiappetta et al, 2004; Czyz et al, 2004; Donato et al, 2004; Chang et al, 2005; Sarhadi et al, 2006; Xu et al, 2004).