Although the efficacy of mTOR inhibition and an antiangiogenic effect have already been reported in similar SCC models (Amornphimoltham et al, 2005), the authors presented no direct link between these two phenomena, and hypothesised that the decrease in the vascular network may represent a direct consequence of the rapid reduction in the tumour size rather than being the cause of such antitumor effect. The gene discussed is MTOR; the disease is neoplasm.