In addition, our data showed that the expression of MMP-1, 7, 9, 11, 13, 14, TIMP-1, and 2, as a function of the cellular type (tumour cell, fibroblast, and/or inflammatory mononuclear cell) expressing the protein, was significantly associated with a shorter relapse-free survival (Table 3 and Figure 2). This evidence concerns the gene TIMP1 and neoplasm.