For instance, for relapsed ALL, the presence of 11q23 abnormalities and Ph1-positive ALL may be linked with a poorer prognosis (Vora et al, 1996; Chessells et al, 2003) whereas survivors with the TEL-AML 1 fusion transcript had an extended second remission period compared with those without (Seeger et al, 1997). Here, ETV6 is linked to acute lymphoblastic leukemia.