Indeed, sialoadhesin copy numbers increased from a median of 3.09×102 copies/104 PBMC to 3.00×103 copies/104 PBMC (p = 0.0016) after HIV-1 seroconversion, suggesting either an increase of sialoadhesin mRNA in a certain cell population, the expansion of a cell population expressing sialoadhesin after HIV-1 infection, or a loss of cells with low sialoadhesin expression, or a combination of these. Here, SIGLEC1 is linked to HIV-1 infection.