Given that the above results clearly suggest that the status of the PPARα locus in the host affects tumor growth, we next evaluated the growth of three PPARα-positive murine tumor models in PPARα KO (S4) animals, including Lewis lung carcinoma (LLC), metastatic B16-F10/GFP melanoma, and B16-BL6 melanoma, p<0.001 (Figure 1E–G). Here, PPARA is linked to melanoma.